This page is built from the open postings on hospital and health-system career sites in South Carolina listed on Betterleap's job board: 4,792 open positions from 42 employers as of October 26, 2026, 2.3% of all open postings on the board, which ranks South Carolina #16 of 51 states. Registered nurses are 48.5% of the state's postings (1,184). Every figure below is a count or a posted pay range, never a job description; the method is at the end.
Where the jobs are in South Carolina
| # | City | Open postings | of which RN | Employers |
|---|---|---|---|---|
| 1 | Charleston, SC | 1,079 | 242 | 8 |
| 2 | Spartanburg, SC | 447 | 109 | 7 |
| 3 | Florence, SC | 417 | 138 | 9 |
| 4 | Columbia, SC | 293 | 112 | 5 |
| 5 | Anderson, SC | 255 | 41 | 4 |
| 6 | Greenville, SC | 190 | 65 | 12 |
| 7 | Conway, SC | 157 | 35 | 4 |
| 8 | Little River, SC | 144 | 47 | 2 |
Every city links to its live listings; the state's registered-nurse listings are at RN jobs in South Carolina.
Health systems hiring the most in South Carolina
Counted by open postings on the system's own career site, so a system that lists every unit and shift separately ranks higher than one that posts one evergreen requisition per role.
| # | Employer | Open postings in SC |
|---|---|---|
| 1 | Medical University of South Carolina Medical Center | 1,728 |
| 2 | McLeod Health | 600 |
| 3 | Spartanburg Regional Healthcare System | 597 |
| 4 | Bon Secours Mercy Health | 496 |
| 5 | AnMed Health | 257 |
| 6 | Universal Health Services | 228 |
| 7 | Conway Medical Center | 160 |
| 8 | Novant Health | 138 |
Which roles South Carolina employers are hiring
| Role | Open postings | Share |
|---|---|---|
| registered nurses | 1,184 | 48.5% |
| medical assistants | 272 | 11.1% |
| physicians | 222 | 9.1% |
| radiologic technologists | 190 | 7.8% |
| licensed practical nurses | 163 | 6.7% |
| patient care technicians | 145 | 5.9% |
| patient access representatives | 139 | 5.7% |
| medical laboratory technologists | 125 | 5.1% |
What nursing jobs pay in South Carolina
For reference, the U.S. Bureau of Labor Statistics counts 49,750 registered nurses employed in South Carolina with a mean wage of $42.15 an hour ($87,670 a year), OEWS May 2025.
Only 2.6% of South Carolina postings state a pay range with both ends: too few to publish a posted median (the rule is at least 100 postings and a median within a third of the BLS mean). The BLS figure above is the reliable reference for this state.
Licensing: working as a nurse in South Carolina
South Carolina is a member of the Nurse Licensure Compact (NLC) according to NCSBN's compact map (read September 26, 2026, which lists 40 member states). A nurse whose primary state of residence is South Carolina can hold a multistate license and practice in every other compact state without a new application, and a nurse with a multistate license issued elsewhere can accept a job in South Carolina without waiting for an endorsement. The state's board of nursing contact page is on NCSBN.
Licensing is issued by the state board of nursing: an approved nursing program, the NCLEX-RN (or NCLEX-PN), a background check and the board's application. The board's own pages are the source of truth for fees and timelines; this page does not restate them.
How this is built
- Scope: open postings on public hospital and health-system career sites, counted as of the date shown; job descriptions are never republished. Only postings whose location is in South Carolina count here; a posting listing several sites counts once, at its first site.
- Pay point: midpoint of the posted range, hourly (annual ÷ 2080), only where both ends and the unit are posted. The top of a posted range is never used as "the pay". A posted median is published only with at least 100 postings and within a third of the BLS mean.
- Freshness: counts are refreshed monthly and the page shows its date; a posting that leaves an employer's site drops out.
- References: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics, May 2025, state estimates; NCSBN Nurse Licensure Compact map data, read September 26, 2026.
Data as of October 26, 2026.
Frequently asked questions
How many open nursing jobs are there in South Carolina right now?
4,792 open postings from 42 hospital and health-system employers in South Carolina as of October 26, 2026, 1,184 of them for registered nurses. Charleston has the most (1,079), then Spartanburg (447).
What do registered nurses earn in South Carolina?
The BLS OEWS May 2025 mean for registered nurses in South Carolina is $42.15 an hour, $87,670 a year, across 49,750 employed RNs. Too few open postings state a pay range for a posted median to be published for this state.
Is South Carolina a Nurse Licensure Compact state?
Yes. South Carolina is an NLC member per NCSBN's compact map (read September 26, 2026), so a multistate license issued by another compact state is valid there.
Which hospitals are hiring nurses in South Carolina?
By open postings on their own career sites: Medical University of South Carolina Medical Center (1,728), McLeod Health (600), Spartanburg Regional Healthcare System (597) and 5 more listed above, as of October 26, 2026.
